Author

B. Roux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Approach:mechanistic / dynamical model· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. Shen· 3 shared E. Perozo· 2 shared A. Bendelac· 1 shared A. Boulanger· 1 shared A. Cerutti· 1 shared A. Donko· 1 shared A. Gaillac· 1 shared A. Pato· 1 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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3 shared papersBiophysics

R. Shen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Dynamics of activation in the voltage-sensing domain of Ci-VSP

S. C. Guo, R. Shen, B. Roux, A. R. Dinner

This study uses molecular dynamics simulations and computational frameworks to elucidate the microscopic mechanism of voltage-sensing domain activation in Ci-VSP.

bioRxiv · Dec 19, 2022 · PreprintBiophysics

Hydrogen Peroxide Production by Epidermal Dual Oxidase 1 Regulates Nociceptive Sensory Signals

A. Pato, K. Bölcskei, A. Donko, D. Kaszas, M. Boros, L. Bodrogi, G. Varady, V. F. Pape, B. Roux, B. Enyedi, Z. Helyes, F. M. Watt, G. Sirokmany, M. Geiszt

The paper shows that DUOX1 in keratinocytes produces hydrogen peroxide, modulating nociceptive signals via TRPA1 and potassium channels in sensory neurons.

bioRxiv · Sep 11, 2022Physiology

State Dependent Anionic Pore Currents Conducted by Single Countercharge Mutants in a Voltage-Sensing Phosphatase

R. Shen, E. Perozo, B. Roux

The paper shows that mutating a countercharge residue in a voltage-sensing phosphatase creates anion-selective omega currents through altered electrostatic potential and water pathways.

bioRxiv · Apr 4, 2022 · PreprintBiophysics

Mechanism of Voltage Gating in the Voltage-Sensing Phosphatase Ci-VSP

R. Shen, Y. Meng, B. Roux, E. Perozo

The paper investigates the voltage gating mechanism of Ci-VSP's voltage-sensing domain using simulations and experiments, identifying four states and charge movement during activation.

bioRxiv · Feb 17, 2022Biophysics

Crystal structure of a bacterial CNNM magnesium transporter

Y. S. Chen, G. Kozlov, J. Armitano, B. J. Moeller, R. Fakih, A. Rohaim, B. Roux, J. E. Burke, K. Gehring

The paper determines the crystal structure of an archaeal CNNM protein bound to Mg2+-ATP, revealing its transmembrane fold and suggesting it functions as a cation transporter.

bioRxiv · Feb 11, 2021Biophysics

Xanthomonas transcriptome inside cauliflower hydathodes reveals bacterial virulencestrategies and physiological adaptation at early infection stages

J. S. Luneau, A. Cerutti, B. Roux, S. Carrere, M.-F. Jardinaud, A. Gaillac, C. Gris, E. Lauber, R. Berthome, M. Arlat, A. Boulanger, L. D. Noel

The paper analyzes the transcriptome of Xanthomonas campestris pv. campestris in cauliflower hydathodes three days post-infection, revealing transcriptional reprogramming and early virulence strategies.

bioRxiv · Jan 19, 2021Microbiology

Biochemical Patterns of Antibody Polyreactivity Revealed Through a Bioinformatics-Based Analysis of CDR Loops

C. T. Boughter, M. T. Borowska, J. J. Guthmiller, A. Bendelac, P. Wilson, B. Roux, E. J. Adams

The paper identifies biochemical determinants of antibody polyreactivity using a bioinformatics pipeline and develops a classifier with over 75% accuracy.

bioRxiv · Jul 30, 2020Immunology