BiochemistrybioRxivPreprint
The inhibitory activity of glycine transporter 2 targeting bioactive lipid analgesics are influenced by formation of a deep lipid cavity
K. A. Wilson, S. N. Mostyn, Z. J. Frangos…·M. L. O'Mara
This study investigates how N-acyl amino acids inhibit GlyT2 by binding to an allosteric site, showing that stereochemistry, tail length, and double bond position enhance inhibition through deep penetration into the binding pocket.
DOI 10.1101/2020.09.10.290908