Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer
K. Ding, L. Chen, K. M. Levine, M. J. Sikora, N. Tasdemir, D. Dabbs, R. Jankowitz, R. S. Hazan, O. S. Shah, J. M. Xavier, A. V. LEE, S. Oesterreich
This study investigates FGFR4's role in endocrine resistance in ER+ breast cancer and finds it does not generally mediate resistance, though HER2-like subtypes may respond to FGFR4 inhibition.
bioRxiv · Mar 18, 2024 · PreprintCancer Biology