K. Ding

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

Modulation of Ideonella sakaiensis PETase active site flexibility and activity on morphologically distinct substrates by surface charge engineering

The paper investigates how surface charge mutations affect PETase activity on different PET substrates and identifies an engineered variant with improved degradation efficiency.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer

This study investigates FGFR4's role in endocrine resistance in ER+ breast cancer and finds it does not generally mediate resistance, though HER2-like subtypes may respond to FGFR4 inhibition.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Blue light stimulated-autofluorescence green flash of lysosome-related organelles in the intestinal cells of nematodes

The paper describes a blue light-induced fluorescence flash in lysosome-related organelles of nematode intestinal cells, suggesting sub-population heterogeneity.

WCRC-25: A novel luminal Invasive Lobular Carcinoma cell line model

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Sniff Olfactometer (SO) Protocols

This paper describes protocols for using a sniff olfactometer to determine odorant thresholds by measuring odorant recognition probabilities associated with odorant concentrations.

Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila

The paper identifies FOXO-dependent gene expression changes in Drosophila under hypoxia, revealing Hipk as a key regulator of hypoxia survival and uncovering FOXO's role in suppressing energy-intensive processes.

Observing noncovalent interactions in experimental electron density for macromolecular systems: A novel perspective for protein-ligand interaction research

The paper introduces a database of non-covalent interactions in protein-ligand complexes using experimental electron density data and demonstrates its application in studying amide-pi interactions.

Novel pectin from crude polysaccharide of Syzygium aromaticum against SARS-CoV-2 activities by targeting 3CLpro

This paper identifies a novel pectin from Syzygium aromaticum that strongly inhibits SARS-CoV-2 replication by binding to 3CLpro, PLpro, and RdRp enzymes.

Exosomal miR-769-5p confers cisplatin resistance and tumorigenesis in gastric cancer

This study identifies exosomal miR-769-5p as a mediator of cisplatin resistance in gastric cancer by targeting CASP9 and promoting apoptosis evasion.

Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

This study shows ESR1 mutant breast cancers exhibit basal cytokeratin expression and immune activation, linked to chromatin reprogramming and paracrine signaling.

Dispatched conformational dynamics couples transmembrane Na+ flux to release of lipid-modified Hedgehog signal

This paper investigates how Na+ flux through DISP1 enables release of lipid-modified Hedgehog signals by analyzing structural and functional changes in DISP1 variants.

Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences

This study analyzes acquired mutations and transcriptional changes in long-term estrogen-deprived breast cancer recurrences, identifying common genetic and expression alterations associated with endocrine resistance.

Susceptibility of tree shrew to SARS-CoV-2 infection

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

Single cell transcriptomic heterogeneity in invasive ductal and lobular breast cancer cells

The paper uses single-cell RNA sequencing to compare transcriptional heterogeneity between invasive ductal and lobular breast cancer cell lines, identifying CDH1 loss effects and potential mediators of ILC-specific features.

Measurement of the torque in braided DNAs using a thermodynamic Maxwell relation

The paper measures torque in braided DNAs using magnetic tweezers and a thermodynamic Maxwell relation, finding torques up to 76 pN·nm and a twist modulus comparable to single DNA.

Circulating bacterial DNA as a tool towards non-invasive biomarkers for colorectal cancer and adenoma

This study identifies circulating bacterial DNA biomarkers for colorectal cancer and adenoma using plasma samples and a random forest model, achieving high accuracy in distinguishing between cancer, adenoma, and healthy controls.

Proteomic and Transcriptomic Profiling Identifies Mediators of Anchorage-Independent Growth and Roles of Inhibitor of Differentiation Proteins in Invasive Lobular Breast Cancer

The paper identifies ID1 and ID3 as novel drivers of anchorage-independent growth in invasive lobular breast cancer through proteomic and transcriptomic profiling.