Author

K. M. Levine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. Oesterreich· 5 shared A. V. Lee· 4 shared N. Tasdemir· 4 shared J. M. Atkinson· 3 shared B. M. Jacobsen· 2 shared K. Ding· 2 shared N. E. Davidson· 2 shared Z. Li· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersCancer Biology

S. Oesterreich

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5 papers

Recent·Most cited

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

Z. Li, Y. Wu, M. E. Yates, N. Tasdemir, A. Bahreini, J. Chen, K. M. Levine, N. M. Priedigkeit, S. Ali, L. Buluwela, S. Arnesen, J. Gertz, J. K. Richer, B. Troness, D. El-Ashry, , S. Oesterreich

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

bioRxiv · Feb 10, 2021 · PreprintCancer Biology

Single cell transcriptomic heterogeneity in invasive ductal and lobular breast cancer cells

F. Chen, K. Ding, N. Priedigkeit, A. Elangovan, K. M. Levine, N. Carleton, L. Savariau, J. M. Atkinson, S. Oesterreich, A. V. LEE

The paper uses single-cell RNA sequencing to compare transcriptional heterogeneity between invasive ductal and lobular breast cancer cell lines, identifying CDH1 loss effects and potential mediators of ILC-specific features.

bioRxiv · Feb 21, 2020Cancer Biology

Proteomic and Transcriptomic Profiling Identifies Mediators of Anchorage-Independent Growth and Roles of Inhibitor of Differentiation Proteins in Invasive Lobular Breast Cancer

N. Tasdemir, K. Ding, K. M. Levine, T. Du, E. A. Bossart, A. V. Lee, N. E. Davidson, S. Oesterreich

The paper identifies ID1 and ID3 as novel drivers of anchorage-independent growth in invasive lobular breast cancer through proteomic and transcriptomic profiling.

bioRxiv · Feb 7, 2019 · PreprintCancer Biology

Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R inhibitors

A. Nagle, K. M. Levine, N. Tasdemir, J. A. Scott, K. Burlbaugh, J. Kehm, T. A. Katz, D. N. Boone, B. M. Jacobsen, J. M. Atkinson, S. Oesterreich, A. V. Lee

This study shows that loss of E-cadherin increases IGF1R pathway activation and makes breast cancers more responsive to anti-IGF1R therapies.

Clinical Cancer Research · Oct 15, 2018Peer-reviewedCancer Biology

Comprehensive 2D and 3D phenotypic characterization of human invasive lobular carcinoma cell lines

N. Tasdemir, E. Bossart, Z. Li, Z. Li, K. M. Levine, B. M. Jacobsen, G. C. Tseng, N. E. Davidson, S. Oesterreich

This paper characterizes the 2D and 3D phenotypes of four human invasive lobular carcinoma cell lines, revealing unique features compared to invasive ductal carcinoma cell lines.

bioRxiv · Jun 7, 2018Cancer Biology