Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration
M. Yang, A. D. James, R. Suman, R. Kasprowicz, M. Nelson, P. O'Toole, W. J. Brackenbury
The paper shows Nav1.5 channels depolarize the membrane potential, increasing Rac1 activation and promoting cell migration.
bioRxiv · Aug 9, 2019Cell Biology