M. Nelson

SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection.

This paper develops a novel microporous biomaterial vaccine platform, VaxMAP, which enhances antibody-mediated immunity against viral infections compared to traditional vaccines.

Cross-species transmission and PB2 mammalian adaptations of highly pathogenic avian influenza A/H5N1 viruses in Chile

The paper tracks the emergence and mammalian adaptation of H5N1 HPAIV in Chile, identifying key mutations in the PB2 gene associated with cross-species transmission.

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

This study identifies a Nav1.5-dependent feedback loop that links extracellular acidification to Na+ influx, promoting breast cancer metastasis.

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across tumor types

The paper evaluates mitochondrial OXPHOS expression and function across murine tumors and normal tissues, finding lower OXPHOS levels in tumors compared to normal and high OXPHOS organs.

Clec12a tempers inflammation while restricting expansion of a colitogenic commensal

This study shows that Clec12a limits inflammation and prevents the expansion of a harmful commensal bacteria, Faecalibaculum rodentium, by enhancing macrophage phagocytosis.

Nanoparticles targeted to fibroblast activation protein outperform PSMA for MRI delineation of primary prostate tumours

This study compares FAP-targeted MRI with PSMA-targeted MRI for delineating prostate tumors in mice, finding FAP provides better contrast enhancement.

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States

This paper introduces a new class of iboga alkaloids, oxa-iboga, which show therapeutic efficacy in opioid use disorder without cardiac risks, as demonstrated in rat models.

Complex basis of hybrid female sterility and Haldane's rule in Heliconius butterflies: Z-linkage and epistasis

This study identifies Z-chromosome epistasis and gene expression changes causing female hybrid sterility in Heliconius butterflies, supporting Haldane's rule in ZW/ZZ taxa.

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

Pangenome of white lupin provides insights into the diversity of the species

The paper constructs a white lupin pangenome to explore genetic diversity and identifies a deletion linked to late flowering, offering insights for breeding improved cultivars.

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

This study shows 17α-estradiol improves metabolic parameters and slows aging in male mice and rats through estrogen receptor α, primarily acting in the liver and hypothalamus.

The Ephrin receptor A2 and Roundabout Guidance Receptor 1 heterodimer: A potential theranostic for squamous cell carcinomas

The paper shows that the EPHA2-ROBO1 heterodimer reduces growth of lung and head and neck squamous cell carcinomas and suggests SLIT2 and Ensartinib as potential therapies.

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

The paper identifies ESCRT pathway components as regulators of tau aggregation propagation by enabling endolysosomal escape of tau seeds.

A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration

The paper shows Nav1.5 channels depolarize the membrane potential, increasing Rac1 activation and promoting cell migration.