R. Kishony

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen

This study shows that de novo mutations in Burkholderia dolosa cause phenotypic switching, with O-antigen loss increasing immune cell uptake but reducing lung competitiveness, depending on infection duration and tissue localization.

Host-parasite coevolution promotes innovation through deformations in fitness landscapes

The paper tests how coevolution between a virus and its bacterial host affects the likelihood of evolutionary innovation by altering fitness landscapes.

Escape mutations circumvent a tradeoff between resistance to beta-lactams and a beta-lactamase inhibitor

The paper identifies escape mutations in the ampC beta-lactamase gene of E. coli that allow resistance to beta-lactams while maintaining resistance to inhibitors, showing drug-specific patterns.