Small-molecule activators of a bacterial signaling pathway inhibit virulence
K. E. Mansour, Y. Qi, M. Yan…·M. M. Schaefers
This study identifies small-molecule activators of the FixLJ pathway in Burkholderia that inhibit virulence without toxicity.
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3 papers
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K. E. Mansour, Y. Qi, M. Yan…·M. M. Schaefers
This study identifies small-molecule activators of the FixLJ pathway in Burkholderia that inhibit virulence without toxicity.
M. O. F. Shaikh, M. M. Schaefers, C. Merakou…·G. P. Priebe
This study evaluates a multicomponent Pseudomonas aeruginosa vaccine combining PopB/PcrH and OprF/I, showing enhanced protection against pneumonia in mice through Th17 responses and functional antibodies.
M. M. Schaefers, B. X. Wang, N. M. Boisvert…·G. P. Priebe
This study shows that evolved variants of the fixLJ pathway in BCC species enhance virulence in host models but reduce survival in soil.