Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects
R. Lasry, N. Maoz, A. W. Cheng, N. Yom Tov, E. Kulenkampff, M. Azagury, H. Yang, C. Ople, S. Markoulaki, D. A. Faddah, K. Makedonski, O. Sabbag, R. Jaenisch, Y. Buganim
This study shows that fibroblasts from pluripotent cells with single-allele knockouts in two pluripotency genes have DNA methylation issues and reduced pluripotency induction ability.
bioRxiv · May 18, 2022 · PreprintCell Biology