Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication
R. LeDesma, A. Biswas, S. Maya, S. Gili, J. Higgins, A. Ploss
This study identifies six cysteines in HEV ORF1 critical for viral replication through divalent cation coordination, revealing domain-domain interactions essential for structure and function.
bioRxiv · Jun 14, 2022Microbiology