Author

A. Ploss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 7 Approach:experimental assay· 5 Organism:mouse· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Research Focus:differential expression· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

F. Douam· 4 shared A. R. Berneshawi· 2 shared M. Saeed· 2 shared S. Maya· 2 shared T. R. Cafiero· 2 shared T. Tamura· 2 shared A. B. Balazs· 1 shared A. Biswas· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

F. Douam

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human liver and immune system

G. Hogan, B. Y. Winer, J. Ahodantin, J. Sellau, T. S. Huang, F. Douam, M. Funaki, L. Chiriboga, L. Su, A. Ploss

This study shows that dually humanized mice can support persistent HBV and HIV coinfections, enabling research on immune dysregulation and immunotherapeutic testing.

bioRxiv · May 13, 2023Microbiology

Hepatitis delta virus RNA decline post inoculation in human NTCP transgenic mice is biphasic

S. Maya, L. Hershkovich, E. F. Cardozo-Ojeda, E. Shirvani-Dastgerdi, J. Srinivas, L. Shektman, S. L. Uprichard, A. R. Berneshawi, T. R. Cafiero, H. Dahari, A. Ploss

The paper characterizes the biphasic decline of HDV RNA post-inoculation in mice and models host-virus dynamics to inform therapeutic development.

bioRxiv · Feb 17, 2023Microbiology

Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

R. LeDesma, A. Biswas, S. Maya, S. Gili, J. Higgins, A. Ploss

This study identifies six cysteines in HEV ORF1 critical for viral replication through divalent cation coordination, revealing domain-domain interactions essential for structure and function.

bioRxiv · Jun 14, 2022Microbiology

Enhancement of Chikungunya virus genome replication in mammalian cells at a sub-physiological temperature

J. Guo, A. E. Lin, C. Aditya, A. Ploss, M. Harris

This study shows that Chikungunya virus replicates more efficiently in mammalian cells at sub-physiological temperatures due to reduced antiviral responses and enhanced stress granule recruitment.

bioRxiv · Sep 29, 2021 · PreprintMicrobiology

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

D. J. Kenney, A. K. O'Connell, J. Turcinovic, P. Montanaro, R. M. Hekman, T. Tamura, A. R. Berneshawi, T. R. Cafiero, S. Al Abdullatif, B. Blum, S. I. Goldstein, B. Heller, H. P. Gertje, E. Bullitt, A. J. Trachtenberg, , F. Douam

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

bioRxiv · Jul 17, 2021 · PreprintMicrobiology

SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation

D. W. Sanders, C. C. Jumper, P. J. Ackerman, D. Bracha, A. Donlic, H. Kim, D. Kenney, I. Castello-Serrano, S. Suzuki, T. Tamura, A. H. Tavares, M. Saeed, A. S. Holehouse, A. Ploss, I. Levental, , C. P. Brangwynne

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

bioRxiv · Dec 14, 2020Cell Biology

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

H. N. Ramanathan, S. Zhang, F. Douam, J. Chang, P. L. Yang, A. Ploss, B. D. Lindenbach

This study identifies VCP/p97 as essential for flavivirus nucleocapsid disassembly using a YFV entry reporter system.

bioRxiv · Oct 22, 2019Microbiology