Author

J. Higgins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Plant Biology· 4 Microbiology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 5 Organism:human· 4 Approach:experimental assay· 3 Organism:plant (other)· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. J. De Vega· 3 shared A. Biswas· 1 shared A. C. Martin· 1 shared A. Enriquez· 1 shared A. Hall· 1 shared A. J. Armstrong· 1 shared A. P. Droop· 1 shared A. Ploss· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 4 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPlant Biology

J. J. De Vega

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, Autophagy, and YB-1 independent manner

T. Imamichi, Q. Chen, B. Sowrirajan, J. Yang, S. Laverdure, A. R. Mele, C. Watkins, J. W. Adelsberger, J. Higgins, H. Sui

This study shows that IL-27 induces HIV-resistant dendritic cells that suppress reverse transcription post-virus entry, independent of SPTBN1, autophagy, and YB-1.

bioRxiv · Jun 12, 2023Immunology

Characterising genome composition and large structural variation in banana varietal groups

J. Higgins, J. A. Osorio-Guarin, C. Olave-Achuri, D. L. Toloza-Moreno, A. Enriquez, F. Di Palma, R. Yockteng, J. J. De Vega

The paper characterizes genome composition and large structural variation in banana varietal groups, identifying introgressions and subgenome composition using new analytical methods.

bioRxiv · Jun 8, 2023 · PreprintPlant Biology

Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

R. LeDesma, A. Biswas, S. Maya, S. Gili, J. Higgins, A. Ploss

This study identifies six cysteines in HEV ORF1 critical for viral replication through divalent cation coordination, revealing domain-domain interactions essential for structure and function.

bioRxiv · Jun 14, 2022Microbiology

Identifying genomic regions and candidate genes selected during the breeding of rice in Vietnam

J. Higgins, B. Santos, T. D. Khanh, K. H. Trung, T. D. Duong, N. T. P. Doai, A. Hall, S. Dyer, L. H. Ham, M. Caccamo, J. J. De Vega

The paper identifies genomic regions and candidate genes selected during rice breeding in Vietnam by analyzing allele frequency patterns and population differentiation across subpopulations.

bioRxiv · Aug 4, 2021 · PreprintPlant Biology

The five Urochola spp. used in development of tropical forage cultivars originate from defined subpopulations with differentiated gene pools

J. Higgins, P. Tomaszewska, T. K. Pellny, V. Castiblanco, J. Arango, J. Tohme, T. Schwarzacher, R. Mitchell, J. S. Heslop-Harrison, J. J. De Vega

The paper analyzes genetic diversity in 111 Urochloa species accessions to identify subpopulations and gene pools, informing breeding strategies for forage grasses.

bioRxiv · Jul 21, 2021 · PreprintPlant Biology

Systems analysis of gut microbiome influence on metabolic disease in HIV and high-risk populations

A. J. Armstrong, K. Quinn, J. Fouquier, S. X. Li, J. M. Schneider, N. M. Nusbacher, K. A. Doenges, S. Fiorillo, T. J. Marden, J. Higgins, N. Reisdorph, T. B. Campbell, B. E. Palmer, C. A. Lozupone

The paper investigates the relationship between gut microbiome, metabolic health, and inflammation in HIV-positive and high-risk men who have sex with men, finding that elevated lipopolysaccharide binding protein (LBP) is a key predictor of metabolic disease.

bioRxiv · Mar 12, 2021Microbiology

A high-content screen profiles cytotoxic microRNAs in pediatric and adult glioblastoma cells and identifies miR-1300 as a potent inducer of cytokinesis failure

M. Boissinot, H. King, M. Adams, J. Higgins, T. A. Ward, L. P. Steele, D. Tams, R. Morton, E. Polson, B. da Silva, A. P. Droop, J. L. Hayes, H. Martin, P. Laslo, E. E. Morrison, , S. C. Short

This study identifies miR-1300 as a potent cytotoxic microRNA in glioblastoma cells, causing cytokinesis failure and apoptosis, with potential therapeutic applications.

bioRxiv · Oct 1, 2019 · PreprintCancer Biology

Exploiting The ZIP4 Homologue Within The Wheat Ph1 Locus Has Identified Two Lines Exhibiting Homoeologous Crossover In Wheat-Wild Relative Hybrids

M.-D. Rey, A. C. Martin, J. Higgins, D. Swarbreck, C. Uauy, P. Shaw, G. Moore

This study identifies two wheat mutants with mutations in TaZIP4-B2 that exhibit homoeologous crossovers in hybrids with wild relatives, offering an alternative to the ph1b mutant for introgression.

bioRxiv · May 26, 2017Plant Biology