Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease
G. T. Heller, F. A. Aprile, T. C. Michaels, R. Limbocker, M. Perni, F. S. Ruggeri, B. Mannini, T. Lohr, M. Bonomi, C. Camilloni, A. De Simone, I. C. Felli, R. Pierattelli, T. P. Knowles, C. M. Dobson, M. Vendruscolo
This paper identifies a small molecule that binds and sequesters monomeric amyloid-β, inhibiting its aggregation and rescuing toxicity in a C. elegans model.
bioRxiv · Sep 16, 2020Biophysics