Author

A. De Simone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Organism:Arabidopsis· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

D. K. Weber· 2 shared E. K. Larsen· 2 shared G. Veglia· 2 shared S. Wang· 2 shared V. U. Reddy· 2 shared A. A. Gupta· 1 shared A. Chiki· 1 shared A. D. Stephens· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

D. K. Weber

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Hydrogen Cyanamide Causes Reversible G2/M Cell Cycle Arrest Accompanied by Oxidation of the Nucleus and Cytosol in Arabidopsis thaliana Root Apical Meristem Cells

Y. Velappan, A. De Simone, S. Signorelli, J. A. Considine, C. H. Foyer, M. J. Considine

bioRxiv · Oct 20, 2022 · PreprintPlant Biology

A Kink in DWORF Helical Structure Controls the Activation of the Sarco-plasmic Reticulum Ca2+-ATPase

V. U. Reddy, D. K. Weber, S. Wang, E. K. Larsen, T. Gopinath, A. De Simone, S. L. Robia, G. Veglia

This study determines the structure of DWORF and shows that a kink caused by Pro15 enables its unique activation of SERCA.

bioRxiv · May 5, 2021Biophysics

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

G. T. Heller, F. A. Aprile, T. C. Michaels, R. Limbocker, M. Perni, F. S. Ruggeri, B. Mannini, T. Lohr, M. Bonomi, C. Camilloni, A. De Simone, I. C. Felli, R. Pierattelli, T. P. Knowles, C. M. Dobson, M. Vendruscolo

This paper identifies a small molecule that binds and sequesters monomeric amyloid-β, inhibiting its aggregation and rescuing toxicity in a C. elegans model.

bioRxiv · Sep 16, 2020Biophysics

Structural Basis for Allosteric Control of the SERCA-Phospholamban Membrane Complex by Ca2+ and cAMP-dependent Phosphorylation

D. K. Weber, M. S. Hernandez, V. U. Reddy, S. Wang, E. K. Larsen, G. Tata, M. Gustavsson, R. L. Cornea, D. D. Thomas, A. De Simone, G. Veglia

This study reveals how phosphorylation and Ca2+ modulate the SERCA-PLN complex through structural changes that enhance Ca2+ transport.

bioRxiv · Aug 28, 2020 · PreprintBiophysics

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of Cyclophilin A

J. Juarez-Jimenez, A. A. Gupta, G. Karunanithy, A. Mey, C. Georgiou, C. Ioannidis, A. De Simone, P. N. Barlow, A. N. Hulme, M. D. Walkinshaw, A. J. Baldwin, J. Michel

The paper uses accelerated MD and MSM to study millisecond timescale conformational dynamics of CypA, identifying key states and validating predictions with NMR.

bioRxiv · Sep 17, 2019Biophysics

Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity

A. D. Stephens, M. Zacharopoulou, R. Moons, G. Fusco, N. Seetaloo, A. Chiki, P. J. Hooper, I. Mela, H. A. Lashuel, J. J. Philips, A. De Simone, F. D. Sobott, G. S. Kaminski Schierle

This study investigates how calcium-induced conformational changes in monomeric alpha-synuclein affect N-terminus exposure and aggregation propensity, identifying sequence-specific conformational differences as key factors.

bioRxiv · Aug 20, 2019 · PreprintBiophysics