Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells.
D. Riegel, E. Romero-Fernandez, M. Simon, A. R. Adenugba, K. Singer, R. Mayr, F. Weber, C. D. Imbusch, M. Kreutz, B. Brors, I. Ugele, J. M. Werner, P. J. Siska, C. Schmidl
The paper integrates single-cell chromatin accessibility and RNA-seq to analyze enhancer landscapes in human tumor-infiltrating T cells, identifying key regulatory elements and their role in TIL dysfunction.
bioRxiv · Mar 16, 2022 · PreprintImmunology