M. Simon

TBX15 regulates a network of immune response genes in adipose tissue and alters fat mass and depot weight in heterozygous knockout mice

Metabolic and transcriptomic analyses of nectaries reveal differences in the mechanism of nectar production between monocots (Ananas comosus) and dicots (Nicotiana tabacum)

This study compares nectar production mechanisms in monocot Ananas comosus and dicot Nicotiana tabacum using transcriptomic and metabolic analyses, revealing differences in sucrose transport and secretion.

Mimosa species endemic to acidic soils in central Brazil are nodulated by a high diversity of Paraburkholderia genotypes, but widespread species are nodulated by Paraburkholderia, Cupriavidus or Rhizobium depending on soil characteristics

This study examines the rhizobia symbionts of Mimosa species in Brazil, finding that endemic species are dominated by Paraburkholderia, while widespread species like M. pudica have a broader range of symbionts including Cupriavidus and Rhizobium, influenced by soil characteristics.

The unusual orf117Sha locus causes desynchronization of pollen development in the Arabidopsis gametophytic Sha CMS

This study identifies orf117Sha as the cause of gametophytic CMS in Arabidopsis, showing pollen death is grain-autonomous and preceded by mitochondrial swelling and developmental desynchronization.

Incorporating strontium enriched amorphous calcium phosphate granules in collagen/collagen-magnesium-hydroxyapatite osteochondral scaffold improves subchondral bone repair

This study shows that adding strontium-enriched amorphous calcium phosphate granules to a collagen scaffold improves subchondral bone repair in a goat model.

Multiple myeloma long-term survivors display sustained immune alterations decades after first line therapy

This study examines immune changes in multiple myeloma survivors years after treatment, finding sustained immune alterations linked to residual disease and therapy.

Assessing diatom-associated bacteria by a specific CARD-FISH protocol

The paper develops a modified CARD-FISH protocol to quantify diatom-associated bacteria by reducing autofluorescence and merging micrographs, showing reliable enumeration of bacterial populations.

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

Sniffing behavior of semi free-ranging Barbary macaques (Macaca sylvanus)

This study observes sniffing behavior in Barbary macaques, finding that sniffs are mostly food-related, more frequent in younger individuals, and influenced by sex and context.

Growth, organic matter release, aggregation and recycling during a diatom bloom: A model-based analysis of a mesocosm experiment

The paper models a diatom bloom in a mesocosm experiment to analyze the role of aggregation, viral lysis, and nutrient stress in bloom termination and organic matter cycling.

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells.

The paper integrates single-cell chromatin accessibility and RNA-seq to analyze enhancer landscapes in human tumor-infiltrating T cells, identifying key regulatory elements and their role in TIL dysfunction.

New Microviridae isolated from Sulfitobacter reveals two cosmopolitan subfamilies of ssDNA phages infecting marine and terrestrial Alphaproteobacteria

The paper isolates a new Microviridae phage and identifies two new subfamilies of ssDNA phages infecting Alphaproteobacteria, showing their cosmopolitan distribution.

Accurate proteome-wide measurement of methionine oxidation in aging mouse brains

This study introduces a method to measure methionine oxidation in mouse brains and finds that oxidation is consistent across individuals but not significantly altered with age.

Nitrogen availability drives gene length of dominant prokaryotes and diversity of genes acquiring Nitrogen-species in oceanic systems

The paper shows that nitrogen availability affects gene length and diversity of nitrogen-acquiring genes in oceanic prokaryotes.

Sweet and magnetic: Succession and CAZyme expression of marine bacterial communities encountering a mix of alginate and pectin particles

The paper studies marine bacterial communities interacting with mixed alginate and pectin particles, finding similar dynamics on both substrates with distinct functional adaptations.

CAZymes in Maribacter dokdonensis 62-1 from the Patagonian shelf: Genomics and physiology compared to related flavobacteria and a co-occurring Alteromonas strain

This study characterizes CAZymes in Maribacter dokdonensis 62-1, showing its ability to utilize alginate and other polysaccharides, and compares its genomic features with related strains and an Alteromonas strain.

Lipidomic analysis of roseobacters of the pelagic RCA cluster and their response to phosphorus limitation

This study reports lipidomic analysis of six RCA roseobacter isolates, revealing unique phospholipid synthesis and adaptation to phosphorus limitation.

A Sea Change in Microbial Enzymes: Heterogeneous latitudinal and depth-related gradients in bulk water and particle-associated enzymatic activities from 30°S to 59°N in the Pacific Ocean

The paper measures hydrolytic enzyme activities in bulk water and particle-associated samples across the Pacific Ocean, revealing heterogeneous latitudinal and depth-related patterns.

Differential degradation of RNA species by autophagy related pathways in plants

The paper identifies autophagy-related RNA degradation in plant vacuoles, showing ATG5's role in RNA transport and processing, while vacuolar RNase2 has minimal impact.

High throughput competitive fluorescence polarization assay reveals functionalredundancy in the S100 protein family

The paper uses a high-throughput fluorescence polarization assay to analyze the functional redundancy and interaction patterns of the human S100 protein family.

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice

This study shows that inhibiting L1 retrotransposition with NRTIs improves health and extends the lifespan of SIRT6 knockout mice by reducing type I interferon response and DNA damage.

MYCN-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

This study shows that MYCN overexpression in neuroblastoma cells rewires metabolism, creating vulnerabilities that can be targeted with metabolic inhibitors.