Author

C. Schmidl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2

Frequent Co-Authors

C. Bock· 2 shared M. Farlik· 2 shared T. Penz· 2 shared A. C. Mueller· 1 shared A. Drori· 1 shared A. F. Rendeiro· 1 shared A. Nemc· 1 shared A. R. Adenugba· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

C. Bock

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

A. Saragovi, X. Zheng, I. Abramovich, L. Cohen-Daniel, L. Zhuoning, H. Raifer, I. Omar, A. Swisa, M. Kuchersky, A. Drori, F. Marini, O. Toker, R. Somech, C. Schmidl, R. C. Hendrickson, , M. Berger

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

bioRxiv · Aug 16, 2022 · PreprintImmunology

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells.

D. Riegel, E. Romero-Fernandez, M. Simon, A. R. Adenugba, K. Singer, R. Mayr, F. Weber, C. D. Imbusch, M. Kreutz, B. Brors, I. Ugele, J. M. Werner, P. J. Siska, C. Schmidl

The paper integrates single-cell chromatin accessibility and RNA-seq to analyze enhancer landscapes in human tumor-infiltrating T cells, identifying key regulatory elements and their role in TIL dysfunction.

bioRxiv · Mar 16, 2022 · PreprintImmunology

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia

A. F. Rendeiro, T. Krausgruber, N. Fortelny, F. Zhao, T. Penz, M. Farlik, L. C. Schuster, A. Nemc, S. Tasnady, M. Reti, Z. Matrai, D. Alpar, C. Bodor, C. Schmidl, C. Bock

This study maps chromatin changes and single-cell immune profiles during ibrutinib treatment in CLL, identifying a shared regulatory program and patient-specific response dynamics.

bioRxiv · Apr 3, 2019Cancer Biology

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

S. Sdelci, A. Rendeiro, P. Rathert, G. Hofstaetter, A. Ringler, H. P. Moll, W. You, K. Klavins, B. Guertl, M. Farlik, S. Schick, F. Klepsch, M. Oldach, P. Buphamalai, F. Schischlik, , S. Kubicek

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.

bioRxiv · Oct 10, 2018Cancer Biology