LTBP1 promotes fibrillin incorporation into the extracellular matrix
M. Przyklenk, V. Georgieva, F. Metzen, S. Mostert, B. Kobbe, G. Sengle, B. Brachvogel, R. Mecham, M. Paulsson, R. Wagener, M. Koch, A. Schiavinato
This study shows LTBP1 coordinates fibrillin-1 and -2 incorporation into the extracellular matrix, with differential roles for its short and long isoforms, revealing a TGFβ-independent function in connective tissue homeostasis.
bioRxiv · Dec 16, 2021Cell Biology