M. Koch

A ligand/receptor trafficking clock governs self-renewal and abscission dynamics in pluripotent stem cells

The paper identifies a ligand/receptor trafficking clock in pluripotent stem cells that regulates self-renewal and abscission dynamics through cyclic turnover of Netrin-1 and its receptors.

Fibre type differences in the organisation of mononuclear cells and myonuclei at the tips of human myofibres

The paper examines differences in mononuclear cells and myonuclei at human myofibre tips, finding more mononuclear cells and COL22A1-expressing nuclei in type II fibres compared to type I.

mTOR controls growth and internal architecture of human breast cancer spheroids

This study investigates how mTOR signaling, through mTORC1 and mTORC2, influences the growth and internal architecture of human breast cancer spheroids.

Genome-wide SNP data reveal recent population structure of Huidobria fruticosa (Loasaceae), a paleo-endemic lineage from the Atacama Desert

The paper uses SNP data from Huidobria fruticosa to show recent population structure shaped by climate change over the last 2 million years in the Atacama Desert.

Structure and dynamics of human cardiac fibroblast nanotubes

This study examines the structure and dynamics of cardiac fibroblast nanotubes in human atrial tissue and cell lines, showing their role in intercellular communication and ECM interaction.

Age-related structural and functional changes of the intracardiac nervous system

This study examines age-related changes in cardiac Schwann cells, parasympathetic nerve fibers, and M2R expression in mice, finding reduced SC density, fewer parasympathetic fibers, and lower M2R expression in aged hearts, which correlates with increased arrhythmia risk.

APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release

The paper investigates how the APP ectodomain regulates gamma-secretase processivity and A beta peptide length, identifying it as a target for Alzheimer's disease therapies.

Dissecting the impact of somatic hypermutation on SARS-CoV-2 neutralization and viral escape

The paper reverts mutations in SARS-CoV-2 antibodies to study SHM's impact on neutralization, finding that some mutations are critical for neutralizing Omicron variants.

Reliable Particle Sizing in Vaccine Formulations using Advanced Dynamic LightScattering

This paper demonstrates advanced dynamic light scattering technology that accurately measures particle size in vaccine formulations without sample dilution, overcoming multiple scattering artifacts.

Single-cell analysis reveals inter- and intratumour heterogeneity in metastatic breast cancer

This study uses single-cell RNA-Seq to identify molecular states and partial EMT phenotypes in breast cancer tumours and metastases, revealing common transcription factors across patients.

Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

The paper develops and evaluates an mRNA vaccine, mRNA-1283, encoding SARS-CoV-2 spike N-terminal and receptor-binding domains, showing improved immunogenicity and protection against multiple variants in mice.

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

This study shows that SARS-CoV-2's ORF8 protein binds to human dendritic cells, induces cytokine storms, and may be a target for therapeutic intervention.

Melt Electrowriting of Scaffolds with a Porosity Gradient to Mimic the Matrix Structure of the Human Trabecular Meshwork

This paper uses melt electrowriting to create scaffolds mimicking the porosity gradient of the human trabecular meshwork, showing cell attachment and viability.

LTBP1 promotes fibrillin incorporation into the extracellular matrix

This study shows LTBP1 coordinates fibrillin-1 and -2 incorporation into the extracellular matrix, with differential roles for its short and long isoforms, revealing a TGFβ-independent function in connective tissue homeostasis.

Consistent predictors of microbial community composition across scales in grasslands reveal low context-dependency

The paper identifies consistent predictors of microbial community composition across grassland scales, finding low context-dependency and predictable variation linked to productivity.

Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved off C5 domain (endotrophin)

The study investigates whether anthrax toxin receptors bind to collagen VI or its cleaved C5 domain (endotrophin) but finds no evidence of such interactions.

No substantial pre-existing B cell immunity against SARS-CoV-2 in healthy adults

The paper analyzes B cell immunity in unexposed adults and finds no substantial pre-existing antibody or B cell response to SARS-CoV-2.

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

mRNA-1273 boosted nonhuman primates show increased neutralizing antibody responses and protection against SARS-CoV-2 beta variant infection.

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants

This study evaluates the neutralizing activity of mRNA-1273 vaccine-induced sera against SARS-CoV-2 variants, finding reduced but still effective neutralization against several variants compared to the wild-type virus.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

This study evaluates mRNA-1273 vaccine efficacy against SARS-CoV-2 B.1.351 in nonhuman primates, finding that two doses significantly reduce viral replication in the airways.

Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

This study shows that mRNA-1273 vaccine-induced antibody responses correlate with protection against SARS-CoV-2 infection in nonhuman primates.

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

Identification of candidate genes for self-compatibility in perennial ryegrass (Lolium perenne L.)

The paper fine maps a QTL for self-compatibility in perennial ryegrass to a 0.26 cM region containing 57 predicted genes, identifying seven candidate genes.

mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

This study evaluates the neutralizing antibody response of mRNA-1273 vaccine against SARS-CoV-2 variants B.1.1.7 and B.1.351 using pseudovirus neutralization assays.

A novel universal algorithm for filament network tracing and cytoskeleton analysis

The paper introduces a new algorithm for tracing filament networks in 2D images and analyzing cytoskeleton structures using advanced microscopy techniques.

LL-37 fights SARS-CoV-2: The Vitamin D-Inducible Peptide LL-37 Inhibits Binding of SARS-CoV-2 Spike Protein to its Cellular Receptor Angiotensin Converting Enzyme 2 In Vitro

This study shows LL-37, a vitamin D-induced peptide, binds to SARS-CoV-2 spike protein and inhibits its interaction with ACE2, potentially preventing viral entry.

Degradation of mixed-linkage (1,3;1,4)-β-D-glucan in maize is mediated by the CAL1 licheninase

The paper identifies CAL1 as a licheninase responsible for degrading mixed-linkage (1,3;1,4)-β-D-glucan in maize, showing its role in regulating MLG content and saccharification efficiency.

Maximizing PHB content in Synechocystis sp. PCC 6803: development of a new photosynthetic overproduction strain.

This paper develops a new Synechocystis sp. PCC 6803 strain that overproduces PHB up to 81% CDW by modifying regulatory and metabolic genes.

The Novel PII-Interacting Regulator PirC (Sll0944) Identifies 3-Phosphoglycerate Mutase (PGAM) as Central Control Point of Carbon Storage Metabolism in Cyanobacteria

This study identifies PirC as a PII-interacting regulator that inhibits PGAM, controlling carbon flux towards glycogen or polyhydroxybutyrate in cyanobacteria under nitrogen limitation.