G. Sengle

PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

Deficiency in hyaluronan synthase 3 attenuates ruptures in a murine model of abdominal aortic aneurysms by reduced aortic monocyte infiltration

This study shows that deficiency in HAS3 reduces aortic ruptures in a murine AAA model by decreasing monocyte infiltration and ECM degradation.

Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

This study shows that targeting MMP-13 prevents aortic aneurysm formation in Marfan mice by reducing collagen degradation and BMP activity.

Inhibition of myeloperoxidase prevents thoracic aortic aneurysm formation in Marfan mice

This study shows that inhibiting myeloperoxidase prevents thoracic aortic aneurysms in Marfan mice by reducing inflammation and extracellular matrix damage.

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory TGFβ-binding site

The paper reveals the cryo-EM structure of fibrillin microfibrils and shows how mutations disrupt TGFβ signaling by blocking LTBP-1 interaction through long-range structural effects.

Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers

The paper identifies transglutaminase-mediated asprosin oligomerization and extracellular fiber formation in connective tissues, suggesting a new mechanism for tissue storage and regulation of asprosin bioavailability.

LTBP1 promotes fibrillin incorporation into the extracellular matrix

This study shows LTBP1 coordinates fibrillin-1 and -2 incorporation into the extracellular matrix, with differential roles for its short and long isoforms, revealing a TGFβ-independent function in connective tissue homeostasis.

Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved off C5 domain (endotrophin)

The study investigates whether anthrax toxin receptors bind to collagen VI or its cleaved C5 domain (endotrophin) but finds no evidence of such interactions.

LL-37 fights SARS-CoV-2: The Vitamin D-Inducible Peptide LL-37 Inhibits Binding of SARS-CoV-2 Spike Protein to its Cellular Receptor Angiotensin Converting Enzyme 2 In Vitro

This study shows LL-37, a vitamin D-induced peptide, binds to SARS-CoV-2 spike protein and inhibits its interaction with ACE2, potentially preventing viral entry.