BiochemistrybioRxiv
Discovery of Aminoglycosides as First in Class, Nanomolar Inhibitors of Heptosyltransferase I
J. A. Milicaj, B. A. Hassan, J. M. Cote…·E. A. Taylor
This study identifies aminoglycosides as the first nanomolar inhibitors of Heptosyltransferase I, with neomycin and kanamycin B being competitive inhibitors and tobramycin showing mixed inhibition.
DOI 10.1038/s41598-022-10776-x