Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma
M. V. Recouvreux, C. M. Galapate, S. Grenier, E. Esparza, Y. Zhang, S. Maganti, R. Naeem, D. A. Scott, A. M. Lowy, H. Tiriac, C. Commisso
This study shows that DON inhibits PDAC growth by targeting asparagine metabolism, and combining DON with ASNase reduces metastasis.
Nature Cancer · Oct 9, 2023Peer-reviewedCancer Biology