T. Hunter

LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment

This study shows that LHPP promotes TNBC growth and metastasis by altering the tumor microenvironment and chemokine signaling.

Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease

The paper examines how the 3D genome landscape and disease influence the functional associations of human genes based on their evolutionary age and lineage restriction.

Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression

This study shows that inhibiting stromal Class I HDACs reduces pancreatic cancer progression by targeting desmoplastic and pro-tumorigenic programs in cancer-associated fibroblasts.

The pharmacopeia of helminth-derived metabolites driving tolerance in dendritic cells

The paper identifies helminth-derived metabolites that reprogram dendritic cells to a tolerogenic phenotype, reducing intestinal inflammation in mice.

LARP4 Is an RNA-Binding Protein That Binds Nuclear-Encoded Mitochondrial mRNAs To Promote Mitochondrial Function

Illuminating histidine phosphorylation in the pancreatic tumor microenvironment

The paper investigates phosphohistidine (pHis) pathway regulation in the mouse pancreatic tumor microenvironment using novel antibodies and identifies deregulated pHis signals and potential substrates.

A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1

This study identifies a novel pathway where MAP4K3 inhibits Sirtuin-1 to suppress LKB1-AMPK, thereby activating mTORC1 in response to amino acids.

Eicosanoids in the pancreatic tumor microenvironment: a multicellular, multifaceted progression

The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.

The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner

The paper shows the D614G mutation in SARS-CoV-2 Spike protein increases infectivity via ACE2 receptor binding.

A non-acidic method using hydroxyapatite and phosphohistidine monoclonal antibodies allows enrichment of phosphopeptides containing non-conventional phosphorylations for mass spectrometry analysis.

This paper introduces a non-acidic method using hydroxyapatite and phosphohistidine antibodies to enrich non-conventional phosphopeptides for mass spectrometry analysis, detecting 425 unique phosphorylation sites.

Defective RNA Polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 Pathway

The paper identifies the SUMO-Ubiquitin-Cdc48 pathway as a negative regulator of RNA polymerase III in budding yeast, leading to proteasomal degradation of Pol III subunits and repression of transcription.