Author

C. Commisso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Approach:wet-lab / biochemical assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. M. Lowy· 2 shared C. M. Galapate· 2 shared G. Lambies· 2 shared H. Tiriac· 2 shared S. Maganti· 2 shared A. Alvarado· 1 shared A. D Ippolito· 1 shared A. E. Clark· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

A. M. Lowy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis

B. Garg, S. Khan, D. Sheikh Babu, E. Mose, K. Gulay, S. Sharma, D. Sood, A. T. Wenzel, A. Martsinkovskiy, J. Patel, D. Jaquish, G. Lambies, A. D Ippolito, K. Austgen, B. Johnston, , A. M. Lowy

This study identifies MICAL2 as a super enhancer-associated gene that promotes pancreatic cancer growth and metastasis through multiple molecular mechanisms.

bioRxiv · Jun 26, 2024 · PreprintCancer Biology

Cell polarity proteins promote macropinocytosis in response to metabolic stress

G. Lambies, S.-W. Lee, K. Duong-Polk, P. Aza-Blanc, S. Maganti, D. W. Dawson, C. Commisso

This study identifies aPKC enzymes as regulators of macropinocytosis in PDAC cells under glutamine stress, showing their role in cell survival and tumor growth.

bioRxiv · Jan 16, 2024Cancer Biology

The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

S. L. Leibel, R. N. McVicar, R. Murad, E. M. Kwong, A. E. Clark, A. Alvarado, B. A. Grimmig, R. Nuryyev, R. E. Young, J. C. Lee, W. Peng, Y. P. Zhu, E. Griffis, C. J. Nowell, B. James, , E. Y. Snyder

This study shows that surfactant proteins mediate an intrinsic inflammatory response in the lung to defend against SARS-CoV-2 infection.

bioRxiv · Jan 26, 2023 · PreprintImmunology

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma

M. V. Recouvreux, C. M. Galapate, S. Grenier, E. Esparza, Y. Zhang, S. Maganti, R. Naeem, D. A. Scott, A. M. Lowy, H. Tiriac, C. Commisso

This study shows that DON inhibits PDAC growth by targeting asparagine metabolism, and combining DON with ASNase reduces metastasis.

bioRxiv · Oct 31, 2022Cancer Biology