R. Nault

Dose-dependent disruption of hepatic zonation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: integration of single-nuclei RNA sequencing and spatial transcriptomics.

This study uses single-nuclei RNA sequencing and spatial transcriptomics to show TCDD disrupts hepatic zonation in mice, leading to fat accumulation and inflammation.

Genome-wide ChIPseq analysis of AhR, COUP-TF, and HNF4 enrichment in TCDD-treated mouse liver

This study identifies genomic binding sites and gene expression changes of AhR, COUP-TFII, and HNF4 in TCDD-treated mouse liver, revealing their interactions in liver function and differentiation.

Dioxin-elicited decrease in cobalamin redirects hepatic propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate accumulation

This study shows TCDD decreases cobalamin, inhibits MUT activity, and redirects propionyl-CoA metabolism to a Cbl-independent β-oxidation-like pathway, leading to acrylyl-CoA accumulation and hepatotoxicity.

Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation

This study shows TCDD induces a futile cycle in hepatic fatty acid metabolism by repressing β-oxidation genes and increasing octenoyl-CoA, which inhibits ECHS1 activity.