State-dependent protein-protein interactions mediating 4-1BB CAR Signaling
S. A. Ritmeester-Loy, J. D. Lautz, Y. Zhang-Wong, J. A. Gustafson, A. L. Wilson, C. Lin, P. R. Gafken, M. C. Jensen, R. Orentas, S. E. Smith
The paper identifies a network of protein interactions activated by 4-1BB CARs upon target engagement and shows that network activation magnitude correlates with IL-2 secretion.
bioRxiv · Jun 7, 2022 · PreprintImmunology