Hypoxia-inducible-factors differentially contribute to clinical disease and the control of viral replication during RSV infection
D. R. Morris, Y. Qu, A. Haas de Mello, Y. L. Jones-Hall, T. Liu, M. Weglarz, T. Ivanciuc, R. P. Garofalo, A. Casola
This study investigates the differential roles of HIF-1 and HIF-2 inhibitors in RSV infection, finding that HIF-1 inhibition worsens disease but reduces viral replication, while HIF-2 inhibition improves clinical outcomes and reduces viral load.
bioRxiv · Aug 15, 2023 · PreprintMicrobiology