Y. Qu

Identification and Characterization of Compounds that Improve Plant Photosynthesis and Growth under Light Stress Conditions.

This study identifies anthraquinone derivatives that improve plant photosynthesis and growth under light stress by enhancing photoprotection without affecting non-stress conditions.

SARS-CoV-2 Omicron BA.2.87.1 Exhibits Higher Susceptibility to Serum Neutralization Than EG.5.1 and JN.1

This study compares the antibody evasion, ACE2 binding, and infectivity of SARS-CoV-2 BA.2.87.1 with EG.5.1 and JN.1, finding BA.2.87.1 has lower immune evasion and reduced infectivity.

Cellular mechanotransduction of human osteoblasts in microgravity

This study investigates how microgravity affects human fetal osteoblasts by measuring cell mechanics and signaling changes in space compared to ground controls.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

MatK impacts Differential Chloroplast Translation of Ribosomal and Photosynthetic genes by limiting spliced tRNA-K(UUU) abundance

The paper investigates how MatK affects chloroplast translation by influencing tRNA-K(UUU) abundance, leading to differential expression of ribosomal and photosynthetic genes.

Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike

This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.

Hypoxia-inducible-factors differentially contribute to clinical disease and the control of viral replication during RSV infection

This study investigates the differential roles of HIF-1 and HIF-2 inhibitors in RSV infection, finding that HIF-1 inhibition worsens disease but reduces viral replication, while HIF-2 inhibition improves clinical outcomes and reduces viral load.

In vivo characterization of a secologanin transporter from Catharanthus roseus

This paper characterizes CrMATE1, a MATE transporter in Catharanthus roseus, as a vacuolar importer of secologanin, showing its role in MIA biosynthesis and its impact on metabolic flux.

The SUMO-interacting Motif in NS2 promotes adaptation of avian influenza virus to mammals

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling

The paper develops DICTrank, a comprehensive list of 1318 human drugs ranked by cardiotoxicity risk using FDA labeling, identifying therapeutic categories with high DICT potential.

The impact of RSV/SARS-CoV-2 co-infection on clinical disease and viral replication: insights from a BALB/c mouse model

This study investigates how RSV and SARS-CoV-2 co-infection affects clinical disease and viral replication in mice, finding that infection timing and viral dose influence disease outcomes.

Gene expression plasticity followed by genetic change during colonization a high-elevation environment

The paper quantifies gene expression plasticity and genetic change in Eurasian Tree Sparrows during high-elevation colonization, showing plasticity is often reversed or reinforced through selection.

ADO-MEDIATED SYNTHESIS OF TAURINE ALTERS THE CHROMATIN LANDSCAPE OF INGUINAL ADIPOSE TISSUE TO ENHANCE NON-SHIVERING THERMOGENESIS

This study shows taurine biosynthesis via ADO enhances NST in inguinal adipose tissue by remodeling chromatin to increase gene transcription for thermogenesis.

Biosynthesis of Kratom Opioids

This study identifies and characterizes enzymes involved in the biosynthesis of kratom opioids, showing their promiscuity for producing derivatives in heterologous systems.

Metagenomic discovery of Candidatus Parvarchaeales related lineages sheds light on the adaptation and diversification from neutral-thermal to acidic-mesothermal environments

This paper identifies new Parvarchaeales lineages through metagenomics and reveals their adaptation strategies to extreme environments via genomic and metabolic analysis.

Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut

This study investigates the spatiotemporal dynamics of microbial engraftment in the gut following fecal microbiota transplantation using a murine model.

FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

Gliotransmission orchestrates neuronal type-specific axon regeneration

This study shows gliotransmission via adenosine signaling determines axon regeneration in specific neuronal types, with implications for CNS repair.

Phospho-proteomic analysis of CAR-T cell signaling following activation by antigen-presenting cancer cells

This paper presents a label-free phospho-proteomic method to analyze CAR-T cell signaling activated by antigen-presenting cancer cells, revealing key pathways like MAPKs and CHK1.

Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing

This study shows anti-ILT3 antibodies block myeloid immunosuppression and enhance tumor killing in solid tumors.

Longitudinal immune cell profiling in early systemic lupus erythematosus

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

GmSALT3 expression improves reactive oxygen species detoxification in salt-stressed soybean roots

The paper uses RNA-seq to show that GmSALT3 improves ROS detoxification in salt-stressed soybean roots by enhancing antioxidant activity and related pathways.

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

The Diameter Factor of Aligned Electrospinning Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization

This study shows that aligned electrospinning membranes with 319 nm diameter enhance skin wound healing by promoting epithelialization and macrophage transformation through IL10 and TGFβ expression.

ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

Application of EGCG modified EDC/NHS cross-linked extracellular matrix to promote macrophage adhesion

The paper develops an EGCG-modified EDC/NHS collagen membrane to enhance macrophage adhesion and vascularization, showing improved cell viability and potential for implant dentistry.

Consideration of macrophage phenotypes under biomaterials mediated host defense process

The paper shows that screening macrophages before analysis is crucial for accurate phenotype identification and that CAMP expression does not fit traditional M1/M2 classification.

Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

This study investigates how different surface topographies of biomaterial scaffolds affect skin wound healing in mice, finding that aligned scaffolds enhance regeneration and modulate immune responses.