Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis
R. Potla, M. Mariko Hirano-Kobayashi, H. Wu, H. Chen, A. Mammoto, B. D. Matthews, D. E. Ingber
The paper identifies a direct mechanical signal transfer pathway between β1 integrin, CD98hc, and TRPV4 channels that mediates ultra-rapid transmembrane mechanochemical conversion in focal adhesions.
bioRxiv · Apr 23, 2019Cell Biology