D. E. Ingber

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

Control of Molecular Biochemistry and Cell Injury Responses through Highly Ordered Supramolecular Assembly of Flavonoids

Molecular dynamic simulations reveal flavonoids self-assemble into ordered structures that interact with proteins, modulate enzyme activity, and protect cells from UV-induced injury.

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips

This paper develops human cervical Organ Chip models to study mucus production, host-microbiome interactions, and immune responses, showing they mimic in vivo conditions and respond to microbiome changes.

Hemoxygenase-1 as a key mediator of acute radiation pneumonitis revealed in a human lung alveolus-on-a-chip

This study uses a human lung alveolus-on-a-chip to show that HMOX-1 mediates acute radiation-induced lung injury and that its activation reduces early injury but worsens later damage.

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip

This paper develops a human vagina-on-a-chip model to study vaginal microbiome-host interactions and their effects on health outcomes.

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

This paper establishes a method to create physiologically relevant oxygen gradients in a microfluidic intestine-on-a-chip model, supporting stable oxygen levels and intestinal barrier integrity.

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

Enhancers of host immune tolerance to bacterial infection discovered using linked computational and experimental approaches

The paper identifies host tolerance mechanisms to bacterial infection using a Xenopus model and multi-omics analysis, finding that metal chelators and HIF-1 agonists enhance survival.

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

This paper demonstrates the formation of lymphoid follicles in a human organ-on-a-chip model and shows improved vaccine responses compared to 2D cultures.

Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus Chip

This study shows that mechanical breathing motions suppress viral replication by enhancing innate immune responses in a human Lung Alveolus Chip model.

Harnessing Colon Chip technology to identify commensal bacteria that promote host tolerance to infection

The paper uses a microfluidic organ-on-a-chip model to identify commensal bacteria that enhance host tolerance to infection, finding Enterococcus faecium promotes tolerance.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

Modular biomaterials vaccine technology protects against multiple pathogens and septic shock

The paper introduces a modular vaccine technology (ciVAX) that protects against multiple pathogens and septic shock by using inactivated bacteria and biomaterial scaffolds.

Human colon-on-a-chip enables continuous in vitro analysis of colon mucus layer accumulation and physiology

This study develops a human colon-on-a-chip model that replicates the mucus bilayer structure and function, enabling real-time non-invasive analysis of mucus layer dynamics.

Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis

The paper identifies a direct mechanical signal transfer pathway between β1 integrin, CD98hc, and TRPV4 channels that mediates ultra-rapid transmembrane mechanochemical conversion in focal adhesions.

Species-specific enhancement of enterohemorrhagic E. Coli pathogenesis mediated by microbiome metabolites

The paper identifies human gut microbiome metabolites that enhance EHEC pathogenesis in a human colonic organ chip model, contributing to species-specific susceptibility.

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties

This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.

Broad spectrum capture of clinical pathogens using engineered Fc-Mannose-Binding Lectin (FcMBL) enhanced by antibiotic treatment

This study demonstrates that FcMBL binds to 86% of pathogen isolates and 90% of pathogen species, including bacteria, fungi, viruses, and parasites, and antibiotic treatment enhances its binding efficiency.