Author

R. Ramani

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Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:software / tool· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Siepel· 2 shared K. Krumholz· 1 shared M. R. Mughal· 1 shared N. E. Dukler· 1 shared Y. Huang· 1 shared Y.-F. Huang· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersEvolutionary Biology

A. Siepel

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2 papers

Recent·Most cited

Extreme purifying selection against point mutations in the human genome

N. E. Dukler, M. R. Mughal, R. Ramani, Y.-F. Huang, A. Siepel

The paper introduces ExtRaINSIGHT to measure purifying selection in the human genome using whole genome sequences, finding ultraselection in specific regions and estimating lethal mutation rates.

bioRxiv · Aug 23, 2021Evolutionary Biology

phastWeb: a web interface for evolutionary conservation scoring of multiple sequence alignments using phastCons and phyloP

R. Ramani, K. Krumholz, Y. Huang, A. Siepel

phastWeb provides a web interface to use phastCons and phyloP for evolutionary conservation scoring without installing PHAST software.

bioRxiv · May 21, 2018Evolutionary Biology