Author

A. Siepel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 6 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Organism:mouse· 2 Organism:rat· 2 Organism:zebrafish· 2

Frequent Co-Authors

I. Gronau· 2 shared M. J. Hubisz· 2 shared N. E. Dukler· 2 shared R. Ramani· 2 shared Y.-F. Huang· 2 shared A. D. Kern· 1 shared A. Durvasula· 1 shared A. L. Gladstein· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersEvolutionary Biology

I. Gronau

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Author profile →

7 papers

Recent·Most cited

Teosinte Pollen Drive guides maize diversification and domestication by RNAi

B. Berube, E. Ernst, J. Cahn, B. Roche, C. de Santis Alves, J. Lynn, A. Scheben, A. Siepel, J. Ross-Ibarra, J. Kermicle, R. A. Martienssen

The paper identifies Teosinte Pollen Drive, an RNAi-based gene drive in maize-teosinte hybrids, and shows its role in maize domestication and diversification through linked genetic elements.

bioRxiv · Jul 12, 2023Plant Biology

Extreme purifying selection against point mutations in the human genome

N. E. Dukler, M. R. Mughal, R. Ramani, Y.-F. Huang, A. Siepel

The paper introduces ExtRaINSIGHT to measure purifying selection in the human genome using whole genome sequences, finding ultraselection in specific regions and estimating lethal mutation rates.

bioRxiv · Aug 23, 2021Evolutionary Biology

Genomic islands of differentiation in a rapid avian radiation have been driven by recent selective sweeps

H. A. Hejase, A. Salman-Minkov, L. Campagna, M. J. Hubisz, I. J. Lovette, I. Gronau, A. Siepel

The paper identifies recent selective sweeps in genomic islands of differentiation in southern capuchino seedeaters, linking them to melanin-based plumage variation and sexual selection.

Proceedings of the National Academy of Sciences · Dec 1, 2020Peer-reviewedEvolutionary Biology

A community-maintained standard library of population genetic models

J. R. Adrion, C. B. Cole, N. Dukler, J. G. Galloway, A. L. Gladstein, G. Gower, C. C. Kyriazis, A. P. Ragsdale, G. Tsambos, F. Baumdicker, J. Carlson, R. A. Cartwright, A. Durvasula, I. Gronau, B. Y. Kim, , A. D. Kern

The paper introduces stdpopsim, a community-maintained library for population genetic models, to standardize simulations and facilitate benchmarking of inference tools.

bioRxiv · Dec 20, 2019Evolutionary Biology

Phylogenetic modeling of regulatory element turnover based on epigenomic data

N. E. Dukler, Y.-F. Huang, A. Siepel

The paper introduces a probabilistic framework to model regulatory element evolution using epigenomic data, finding enhancers turnover rates are higher than promoters and correlated with genomic features.

bioRxiv · Sep 18, 2019Evolutionary Biology

Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph

M. J. Hubisz, A. L. Williams, A. Siepel

This paper introduces ARGweaver-D, a method to detect ancient gene flow between hominins by analyzing genomic data from humans, Neanderthals, and Denisovans.

bioRxiv · Jun 30, 2019Evolutionary Biology

phastWeb: a web interface for evolutionary conservation scoring of multiple sequence alignments using phastCons and phyloP

R. Ramani, K. Krumholz, Y. Huang, A. Siepel

phastWeb provides a web interface to use phastCons and phyloP for evolutionary conservation scoring without installing PHAST software.

bioRxiv · May 21, 2018Evolutionary Biology