Y.-F. Huang

Transcription factor binding sites are frequently under accelerated evolution in primates

The paper identifies over 6,000 transcription factor binding sites (TFBSs) under accelerated evolution in primates, suggesting their role in neurodevelopmental divergence.

Mixture Density Regression reveals frequent recent adaptation in the human genome

This paper introduces Mixture Density Regressions (MDRs) to analyze recent adaptation in the human genome and finds that positive selection is relatively common, with several genomic factors associated with adaptation.

Extreme purifying selection against point mutations in the human genome

The paper introduces ExtRaINSIGHT to measure purifying selection in the human genome using whole genome sequences, finding ultraselection in specific regions and estimating lethal mutation rates.

Dissecting genomic determinants of positive selection with an evolution-guided regression model

The paper introduces MK regression, a statistical model that identifies genomic features driving positive selection in chimpanzees, revealing new factors like gene expression level and metabolic genes.

Phylogenetic modeling of regulatory element turnover based on epigenomic data

The paper introduces a probabilistic framework to model regulatory element evolution using epigenomic data, finding enhancers turnover rates are higher than promoters and correlated with genomic features.