Author

M. R. Mughal

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Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. Siepel· 1 shared M. DeGiorgio· 1 shared N. E. Dukler· 1 shared R. Ramani· 1 shared Y.-F. Huang· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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1 shared paperEvolutionary Biology

A. Siepel

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivAug 23, 2021

Extreme purifying selection against point mutations in the human genome

N. E. Dukler, M. R. Mughal, R. Ramani…·A. Siepel

The paper introduces ExtRaINSIGHT to measure purifying selection in the human genome using whole genome sequences, finding ultraselection in specific regions and estimating lethal mutation rates.

DOI 10.1038/s41467-022-31872-6

humanwhole-genome sequencing

𝕏 PostBluesky

Evolutionary BiologybioRxivSep 5, 2018

Localizing and classifying adaptive targets with trend filtered regression

M. R. Mughal, M. DeGiorgio

This paper introduces Trendsetter, a method for detecting and classifying genomic regions under natural selection, showing it is robust to missing data and background selection.

DOI 10.1093/molbev/msy205

humanwhole-genome sequencing

𝕏 PostBluesky