Author

R. Sobecks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. M. Zidan· 1 shared B. Hamilton· 1 shared B. K. Jha· 1 shared B. Tomlinson· 1 shared C. Hong· 1 shared C. Schuerger· 1 shared E. D. Hsi· 1 shared H. Carraway· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. M. Zidan

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Resistance to decitabine and 5-azacytidine emerges from adaptive responses of the pyrimidine metabolism network

X. Gu, R. Tohme, B. Tomlinson, M. Hasipek, L. Durkin, C. Schuerger, A. M. Zidan, T. Radivoyevitch, C. Hong, H. Carraway, B. Hamilton, R. Sobecks, B. K. Jha, E. D. Hsi, J. Maciejewski, Y. Saunthararajah

This paper identifies adaptive metabolic responses in pyrimidine metabolism as a mechanism of resistance to decitabine and 5-azacytidine, and shows that alternating these drugs with metabolic inhibitors can extend DNMT1 depletion and delay leukemia relapse.

bioRxiv · Feb 20, 2020Cancer Biology