Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
K. F. Yambire, L. Fernandez-Mosquera, R. Steinfeld, C. Muehle, E. Ikonen, I. Milosevic, N. Raimundo
This study identifies a transcriptional repression of mitochondrial biogenesis in lysosomal storage diseases through KLF2 and ETV1, showing their roles in disease mechanisms.
bioRxiv · Feb 6, 2019Cell Biology