Author

E. Ikonen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Kanerva· 2 shared L. Paavolainen· 2 shared S. Li· 2 shared V. T. Salo· 2 shared A. Kyttala· 1 shared A. S. di Frega· 1 shared C. Muehle· 1 shared C. Raiborg· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

K. Kanerva

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Author profile →

6 papers

Recent·Most cited

One-step generation of auxin-inducible degron cells with high-efficiency homozygous tagging

S. Li, Y. Wang, M. v. d. Stoel, X. Zhou, S. Madhusudan, K. Kanerva, V. D. Nguyen, N. Eskici, V. M. Olkkonen, Y. Zhou, T. Raivio, E. Ikonen

This paper introduces a one-step genome editing method for high-efficiency homozygous tagging of endogenous proteins with auxin-inducible degron in human cells, achieving >80% efficiency in A431 cells and >50% in H9 ES cells.

bioRxiv · Mar 26, 2023 · PreprintCell Biology

ATPase activity of DFCP1 controls selective autophagy

V. Nähse, C. Raiborg, K. W. Tan, S. Mørk, M. L. Torgersen, E. M. Wenzel, M. Nager, V. T. Salo, T. Johansen, E. Ikonen, K. O. Schink, H. Stenmark

This study identifies DFCP1 as an ATPase essential for omegasome constriction and selective autophagy by facilitating autophagosome release.

bioRxiv · Feb 24, 2022Cell Biology

Multiparametric Platform for Profiling Lipid Trafficking in Human Leukocytes: Application for Hypercholesterolemia

S. G. Pfisterer, I. Brock, K. Kanerva, I. Hlushchenko, L. Paavolainen, P. Ripatti, M. M. Islam, A. Kyttala, M. D. Di Taranto, A. S. di Frega, G. Fortunato, J. Kuusisto, P. Horvath, S. Ripatti, M. Laakso, E. Ikonen

The paper develops a high-content imaging platform to quantify lipid trafficking in leukocytes, showing lipid mobilization correlates with LDL uptake and helps distinguish hypercholesterolemia cases.

bioRxiv · Apr 19, 2021Cell Biology

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the ER membrane

X. Prasanna, V. T. Salo, S. Li, K. Ven, H. Vihinen, E. Jokitalo, I. Vattulainen, E. Ikonen

This study shows seipin traps triacylglycerols in the ER membrane via its luminal hydrophobic helices, facilitating their nanoscale clustering and promoting TAG transfer to lipid droplets.

bioRxiv · Oct 26, 2020Cell Biology

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

K. F. Yambire, L. Fernandez-Mosquera, R. Steinfeld, C. Muehle, E. Ikonen, I. Milosevic, N. Raimundo

This study identifies a transcriptional repression of mitochondrial biogenesis in lysosomal storage diseases through KLF2 and ETV1, showing their roles in disease mechanisms.

bioRxiv · Feb 6, 2019Cell Biology

Association of tamoxifen resistance and lipid reprogramming in breast cancer.

S. Hultsch, M. Kankainen, L. Paavolainen, R.-M. Kovanen, E. Ikonen, S. Kangaspeska, V. Pietiaeinen, O. Kallioniemi

This study identifies lipid reprogramming and lysosomal membrane permeabilization (LMP) prevention as key mechanisms of tamoxifen resistance in breast cancer, suggesting new therapeutic targets.

bioRxiv · Jun 25, 2018Cancer Biology