Cell BiologybioRxivPreprint
Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity
I. Riera-Tur, T. Schaefer, D. Hornburg…·I. Dudanova
This study shows that amyloid-like aggregates impair lysosomal function in neurons by sequestering AP-31, leading to neurotoxicity.
DOI 10.1101/2019.12.16.877431