Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients
L. Haupt, A. Maus, M. Tiburcy, S. Koehne, W. Maurer, R. Tappu, J. Haas, Y. Li, A. Sasse, C. Santos, R. Dressel, L. Wojnowski, G. Bunt, A. M. Shah, B. Meder, , K. Streckfuss-Bömeke
This study develops a human iPSC-CM model of DOX-induced cardiac dysfunction in B-cell lymphoma patients with high-dose DOX treatment, showing increased susceptibility to DOX toxicity and impaired mechanical function.
bioRxiv · Apr 15, 2020Cell Biology