J. Haas

Systemic Lupus Erythematosus Serum Stimulation of Human Intestinal Organoids Induces Changes in Goblet Cell Differentiation and Mitochondrial Fitness

This study shows that SLE serum affects intestinal organoids by altering mucus, mitochondrial fitness, and gene expression, linking gut barrier dysfunction to autoimmune disease.

A novel nongenetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosis

This paper establishes a nongenetic mouse model to study atherosclerosis under hyperlipidemia and hyperglycemia conditions and evaluates diet effects on plaque severity.

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients

This study develops a human iPSC-CM model of DOX-induced cardiac dysfunction in B-cell lymphoma patients with high-dose DOX treatment, showing increased susceptibility to DOX toxicity and impaired mechanical function.

Asparagine deprivation causes a reversible inhibition of Human Cytomegalovirus acute virus replication

This study identifies asparagine as a critical factor for HCMV replication through a large-scale siRNA screen, showing that its depletion inhibits virus replication but allows recovery with exogenous asparagine.

Spatial and temporal control of norovirus protease activity is determined by polyprotein processing and intermolecular interactions within the viral replication complex.

This study investigates how norovirus protease activity is regulated by polyprotein processing and intermolecular interactions within the replication complex, showing that precursor forms are active in vitro but their activity in cells depends on localization and substrate access.