Structural Basis for the Inhibition of IAPP Fibril Formation by the Hsp60 Co-Chaperonin Prefoldin
R. Toerner, T. Kupreichyk, L. Gremer, E. Colas Debled, D. Fenel, P. Gans, D. Willbold, G. Schoehn, W. Hoyer, J. Boisbouvier
This study shows how prefoldin inhibits IAPP fibril formation by binding to the N-terminal segment of IAPP on fibril surfaces and ends, reducing aggregate size and number.
bioRxiv · Oct 20, 2021Biophysics