Cancer BiologybioRxivPreprint
A diffusion-like process enables expansion of advantaged gene mutations in human colonic epithelium
Cora Olpe, Doran Khamis, Maria Chukanova…·Douglas J Winton
The paper quantifies clonal expansion of KDM6A-negative mutations in human colonic epithelium and proposes crypt diffusion as a mechanism for accommodating clonal growth.