Rahul Sharma

Uptake of CD36 and its natural and therapeutic ligands by clathrin-mediated endocytosis

This study shows CD36 and its ligands are internalized via clathrin-mediated endocytosis, not caveolae, and disrupting clathrin inhibits ligand uptake and PROTAC-induced degradation.

NCI-Profiler: automated protein-ligand interaction detection and visualization

NCI-Profiler detects and visualizes nine types of protein-ligand non-covalent interactions with high accuracy and speed, outperforming existing tools in several categories.

SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function

This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.

The Impact of Non-coding G-quadruplex Variants on Human Traits and Disease Susceptibility

The paper identifies non-coding G-quadruplex variants associated with plasma proteins and clinical traits, showing stronger signals when considering G4 stability impacts and integrating with protein-truncating variants.

Clonal haematopoiesis without identified genetic drivers: insights from analyses of 407,512 individuals

This study identifies 26,963 individuals with clonal haematopoiesis without known genetic drivers (CH-UD) and finds strong genetic and phenotypic links to other forms of clonal haematopoiesis, implicating TCL1A and epigenetic changes.

BLOC1S1 regulates autolysosomal and exosomal dynamics during CD4⁺ T cell differentiation

This study shows BLOC1S1 deficiency in CD4+ T cells leads to altered lysosomal and exosomal dynamics, enhancing Th2 immune responses through exosome-mediated cytokine export.

ISG15 orchestrates dynamic crosstalk between mitochondrial fat oxidation and type 1 interferon in myeloid cells

This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.