Benjamin H. Schwarz

This study shows that proteasome mutations in CANDLE syndrome disrupt neuronal development by increasing polyamine levels through ODC dysregulation, and inhibiting ODC can reverse these effects.

This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.

This study shows a ketogenic diet reprograms host and microbiome functions to enhance tissue regeneration through IL-17A activation and microbial riboflavin and sphingomyelinase pathways.

This paper identifies trehalose monocorynomycolate (TMCM) from C. mast as a stimulator of IL-17-producing γδ T cells at the ocular surface, which protects against corneal infection.

This study identifies how glucose and CO2 synergistically regulate toxin production in Bacillus anthracis through the AtxA transcription factor and its interaction with the glucose-PTS system.

This study models how diet affects viral shedding and spillover risk in Jamaican fruit bats infected with H18N11, finding diet-dependent interactions between citrulline and TNF influence shedding and transmission.

This study identifies mitochondrial hyperactivity and reactive oxygen species as critical drivers of innate immunity to the YFV-17D vaccine, enhancing IFN response and vaccine effectiveness.

The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.

This study investigates amino acid acquisition pathways in Borrelia burgdorferi, revealing that peptide and free amino acid transport are essential for growth and motility but dispensable during tick colonization.

The study shows diet affects viral shedding in Jamaican fruit bats, with suboptimal-sugar diets leading to higher viral RNA shedding than suboptimal-fat diets.

This study shows that lipin-1 limits macrophage lipid synthesis, which supports inflammation resolution by enhancing efferocytosis.

This study develops an intranasal influenza vaccine using spike nanobicelles that elicit pan-H1 antibodies and provide protection against diverse H1N1 viruses.

This study shows that Legionella pneumophila replication depends on host membrane acyl chain composition, with palmitoleic acid promoting membrane disorder and enhancing bacterial growth.