Developmental BiologybioRxivPreprint
Self-organized mechanochemical instabilities drive the emergence of digit tissue morphogenesis
Rio Tsutsumi, Antoine Diez, Steffen Plunder…·Mototsugu Eiraku
The paper develops a limb-mesenchymal organoid system and models to show that digit-like structures form through mechanochemical instabilities involving cell adhesion, chemotaxis, and convergent-extension.
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