Modelling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis
Sneha Pandya, Pedro D. Maia, Benjamin S. Freeze…·Ashish Raj
This study uses a Network Diffusion Model to show that structural brain networks drive pathological spread in ALS, with seed regions in basal ganglia, thalamus, and insula, not the primary motor cortex.