Pharmacology & ToxicologyMolecular PharmacologyPeer-reviewed
Inhibition of constitutive activity of the atypical chemokine receptor ACKR3 by the small-molecule inverse agonist VUF16840
Reggie Bosma, Desislava N. Nesheva, Merel Rijnsburger…·Rob Leurs
This study characterizes VUF16840 as a selective inverse agonist of ACKR3 that inhibits constitutive and chemokine-induced signaling by stabilizing the inactive conformation of the receptor.
5 citations