Enterococcal cell wall remodelling underpins pathogenesis via the release of the Enteroccocal Polysaccharide Antigen (EPA)
Robert E Smith, Bartosz J. Michno, Lowrence Rene Christena, Finn O’Dea, Jessica L. Davis, Ian D. E. A. Lidbury, Marcel G. Alamán-Zárate, Danai Stefanidi, Emmanuel Maes, Hannah M. Fisher, Tomasz K. Prajsnar, Stéphane Mesnage
This paper identifies AtlE, an N-acetylmuramidase essential for virulence in E. faecalis, showing its role in cell wall remodelling and immune evasion via the release of EPA-containing fragments.
PLoS Pathogens · Jun 23, 2025Peer-reviewedMicrobiology