Tomasz K. Prajsnar

This study identifies non-canonical autophagy pathways, including LC3-associated phagocytosis and STIL, that mediate host defense against pneumococcal infection in zebrafish.

The paper identifies pulsatile Class I PI3K activity on neutrophil phagosomes during bacterial infection, suggesting phagosomes reopen and reclose to release or restart digestion.

This paper identifies AtlE, an N-acetylmuramidase essential for virulence in E. faecalis, showing its role in cell wall remodelling and immune evasion via the release of EPA-containing fragments.

This study shows that S. aureus uses autophagy to create an intracellular niche in neutrophils, while p62-mediated autophagy protects the host.